Apolipoprotein A-I Is a Potential Mediator of Remote Ischemic Preconditioning

Apolipoprotein A-I Is a Potential Mediator of Remote Ischemic Preconditioning

BACKGROUND Remote ischemic preconditioning (RIPC) has emerged as an attractive strategy in clinical settings. Despite convincing evidence of the critical role played by circulating humoral mediators, their actual identities remain unknown. In this study, we aimed to identify RIPC-induced humoral mediators using a proteomic approach. METHODS and Results Rats were exposed to 10-min limb ischemi...

Remote Ischemic Preconditioning and Diabetic Macular Edema

Objective: Remote Ischemic Preconditioning (RIPC) as the transient ischemia and reperfusion of the arm is a promising method for protecting different tissue from future ischemia. These effects might be mediated through vascular and endothelial growth factor (VEGF) pathway. We investigated the influence of RIPC on diabetic macular edema (DME) as a chronic ischemic condition in patients who were ...

Remote Ischemic Preconditioning

Ischemic Preconditioning Ischemic preconditioning is a widely accepted concept, first introduced in 1986 by Murray et al,1 who showed in an animal experiment that multiple brief periods (5 min) of coronary artery occlusion dramatically reduced infarct size because of the subsequent sustained coronary occlusion. Numerous reports have followed and supported the concept. The mechanism of ischemic ...

Effect of Remote Ischemic Preconditioning on Troponin I in CABG

Background Elective open heart surgery is associated with troponin release in some cases due to myocyte necrosis. Objectives The aim of this study was to measure cardiac troponin I (cTnI) preoperatively in elective CABG after remote ischemic preconditioning. Methods Twenty-eight patients were selected for elective CABG. They were randomized to receive remote ischemic preconditioning (induce...

Is nitrite the circulating endocrine effector of remote ischemic preconditioning?